Integrated Fluidic Circuits (IFC) with NanoFlex™ Valves


Fluidigm's IFC's are microfluidic-based chips that can be used with analytical instruments for biological research. The IFC's are based on regulating the solution flowing through the channels on a micro-, nano-, or even picoliter-scale. The technology was developed in 1998 by Dr. Stephen Quake and his group at the California Institute of Technology with the development of a fabrication process called Multilayer Soft Lithography (MSL®). The process uses rubber that deflects under pressure to create an effective seal. The NanoFlex™ valve is the foundation of Fluidigm’s various integrated fluidic circuits. It consists of a membrane that deflects under pressure to pinch off the flow of fluids in a microchannel. The valve is made from two separate layers of elastomeric rubber that have been placed on a micro-machined mold. By bonding the layers together, the recesses form channels and chambers in a rubber chip.  When pressurized gas is applied to the channels in one layer of the chip, the rubber deflects at precisely the intersection of the channels in the bottom layer.

Fluidigm sells several models of IFCs that can be used with accompanying analytical instruments sold by the company. The first products were released in 2003.

Product Released: 
January, 2003
Information Verified: 
March, 2013

Californa Locations:

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