RONDEL™ (RNAi/Oligonucleotide Nanoparticle Delivery) technology

Description:

The RONDEL system is a nanoparticle drug delivery platform for siRNA therapeutics.

"The RONDEL system takes advantage of molecular forces to generate self-assembly of an siRNA containing nanoparticle therapeutic. DNA and RNA are linear, negatively charged molecules. Component one of RONDEL is a linear polymer in which positively charged groups alternate with sugar molecules (cyclodextrin). Upon mixing with siRNA, the positively charged polymer associates with the negatively charged backbone of siRNAs. Several polymer/siRNA complexes self-assemble into a nanoparticle of less than 100nm in diameter that fully protects the siRNA from degradation in serum. This size is key to the delivery of the siRNA payload to tumor cells. Components two and three of the system contain adamantane covalently bound to polyethylene glycol (PEG). Adamantane is highly water insoluble. In aqueous solution, the adamantane end of the complex associates with the hydrophobic cores in the cyclodextrin polymer while the hydrophilic PEG extends from the hydrophobic core. The result is a siRNA containing nanoparticle coated with PEG, which acts to stabilize the nanoparticle and prevent aggregation under physiological conditions. A variety of targeting molecules that selectively attach to specified cell surface receptors can be covalently attached to the adamantane-PEG modifier, enabling the siRNA-containing particles to be coated with targeting molecules that address the nanoparticle to the tissue of interest. The siRNA delivery system has been designed for intravenous injection."

Information Verified: 
April, 2013

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